Initialising ...
Initialising ...
Initialising ...
Initialising ...
Initialising ...
Initialising ...
Initialising ...
Hamada, Nobuyuki*; Iwakawa, Mayumi*; Imadome, Kaori*; Funayama, Tomoo; Sakashita, Tetsuya; Sora, Sakura*; Ni, M.*; Imai, Takashi*; Kobayashi, Yasuhiko
Journal of Radiation Research, 50(Suppl.A), P. A118, 2009/05
Nishikino, Masaharu; Okano, Yasuaki*; Sato, Katsutoshi*; Hasegawa, Noboru; Ishino, Masahiko; Oshima, Shinsuke*; Kawachi, Tetsuya; Numasaki, Hodaka*; Teshima, Teruki*; Nishimura, Hiroaki*
no journal, ,
Recently, high energy, monochromatic X-rays emanating from laser-produced plasma (LPP) are attracting much attention as a new radiation source indispensable for high energy density physics, bioscience, and material sciences. Aiming at these applications, we have been improving performances of Ka lines emitted from and soft X-ray lasers. The monochromaticity is particularly important when X-rays are handled with a narrow-band optics or used to selectively excite a specific material involved in matters. In addition, time-duration of such sources is typically an order of pico-second, and it could be comparable or even shorter than recovery time of radiatively-damaged biological cell, so that the LPP source can be a new source for investigating the mechanisms of irradiation survival and death of biological cells. We propose to develop an ultrashort, intense X-ray microbeam system to study the radiobiological effect and the bystander effect.
Sakashita, Tetsuya; Suzuki, Michiyo; Hamada, Nobuyuki*; Fukamoto, Kana; Yokota, Yuichiro; Kakizaki, Takehiko*; Wada, Seiichi*; Funayama, Tomoo; Kobayashi, Yasuhiko
no journal, ,
To investigate the neurogenesis-independent effects of ionizing radiation on the nervous system, we have used a nematode, , in adult. Recently, we found the modulatory effects of 
-rays on the salt chemotaxis learning in 
. Biological effectiveness is known to differ with the linear energy transfer (LET) of radiation: A high-LET radiation causes more dense ionization along their trajectories, and induces more serious biological effects, compared with low-LET radiations such as -rays. Thus, this study aims to address the effects of high-LET carbon ions on the salt chemotaxis learning in. Moreover, localized ionizing irradiation is a useful probe to analyzing radiation effects at a cellular or tissue level. To investigate the effects on the neuronal tissue (a nerve ring), we used the heavy-ion microbeam system at the Takasaki Ion accelerators for Advanced Radiation Application (TIARA) of JAEA.
Funayama, Tomoo; Fukamoto, Kana; Sakashita, Tetsuya; Yokota, Yuichiro; Suzuki, Michiyo; Kobayashi, Yasuhiko
no journal, ,
Heavy-ion microbeam irradiation is a useful means for analyzing important biological subjects such as cellular responses to low dose irradiation, radiation-induced bystander effects, and the biological track structure of charged particles. The microbeam system at JAEA-Takasaki has been operated since early 1990's, and has contributed to analyze the effect of heavy-ion irradiation on not only cultured cells but also biological systems. However, the microscope of existing targeting system becomes decrepit and inoperative in part, and difficult to repair by lacking of maintenance parts. Therefore we recently updated whole targeting system to newly designed one. Additionally, to irradiate this finer microbeam to the specific region of individual cells, a new cell targeting system was designed and installed under the beam extraction window of focusing heavy-ion microbeam system, which is newly developed.